Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection-Reference-Cited by-同舟云学术

Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Jiménez de Oya Nereida¹^ORCID,San-Félix Ana²,Casasampere Mireia³,Blázquez Ana-Belén¹^ORCID,Mingo-Casas Patricia¹,Escribano-Romero Estela¹^ORCID,Calvo-Pinilla Eva¹,Poderoso Teresa¹,Casas Josefina³⁴,Saiz Juan-Carlos¹,Pérez-Pérez María-Jesús²,Martín-Acebes Miguel A.¹^ORCID

Affiliation:

1. ZOOVIR, Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

2. Instituto de Quimica Medica (IQM), CSIC, Madrid, Spain

3. Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC), CSIC, Barcelona, Spain

4. Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

Abstract

The flavivirus life cycle is strictly dependent on cellular lipid metabolism. Polyphenols like gallic acid and its derivatives are promising lead compounds for new therapeutic agents as they can exert multiple pharmacological activities, including the alteration of lipid metabolism.

Funder

MEC | Agencia Estatal de Investigación

MEC | Consejo Superior de Investigaciones Científicas

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01687-22

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