Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes-Reference-Cited by-同舟云学术

Single- and Multistep Resistance Selection Studies on the Activity of Retapamulin Compared to Other Agents against Staphylococcus aureus and Streptococcus pyogenes

Published:2006-02 Issue:2 Volume:50 Page:765-769
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kosowska-Shick Klaudia¹,Clark Catherine¹,Credito Kim¹,McGhee Pamela¹,Dewasse Bonifacio¹,Bogdanovich Tatiana¹,Appelbaum Peter C.¹

Affiliation:

1. Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033

Abstract

ABSTRACT Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes , with a slow and gradual propensity for resistance development in S. aureus .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.2.765-769.2006

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