Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double‐blind, placebo‐controlled Phase 2 trial

Author:

Weiss Anne12,Delavenne Emilie1,Matias Carina1,Lagler Heimo3,Simon Daniel1,Li Ping1,Hansen Jon U.4,dos Santos Teresa Pires5,Jana Bimal5,Priemel Petra6,Bangert Christine7,Bauer Martin8,Eberl Sabine8,Nussbaumer‐Pröll Alina8,Anne Österreicher Zoe8,Matzneller Peter8,Quint Tamara7,Weber Maria8,Nielsen Hanne Mørck6,Rades Thomas6,Johansen Helle Krogh910,Westh Henrik11,Kim Wooseong12,Mylonakis Eleftherios12,Friis Christian5,Guardabassi Luca5,Pace John1,Lundberg Carina Vingsbo4,M'Zali Fatima13,Butty Pascal14,Sørensen Nikolaj15,Nielsen Henrik Bjørn15,Toft‐Kehler Rasmus1,Guttman‐Yassky Emma16,Stingl Georg7,Zeitlinger Markus8,Sommer Morten12ORCID

Affiliation:

1. UNION Therapeutics Hellerup Denmark

2. Novo Nordisk Foundation for Biosustainability Technical University of Denmark Lyngby Denmark

3. Department of Medicine 1, Division of Infectious Diseases and Tropical Medicine Medical University of Vienna Wien Austria

4. Department of Bacteria, Parasites and Fungi Statens Serum Institut Copenhagen Denmark

5. Department of Veterinary and Animal Sciences University of Copenhagen Frederiksberg C Denmark

6. Department of Pharmacy University of Copenhagen Copenhagen Denmark

7. Department of Dermatology Medical University of Vienna Wien Austria

8. Department of Clinical Pharmacology Medical University of Vienna Wien Austria

9. Department of Clinical Microbiology Rigshospitalet Copenhagen Denmark

10. Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

11. Hvidovre Hospital Hvidovre Denmark

12. Warren Alpert Medical School of Brown University, Division of Infectious Diseases, Rhode Island Hospital Providence Rhode Island USA

13. University of Bordeaux Bordeaux Cede

14. CEVA Santé Animale Libourne France

15. Clinical Microbiomics Copenhagen Denmark

16. Icahn School of Medicine at Mount Sinai New York New York USA

Publisher

Wiley

Subject

Molecular Medicine,Medicine (miscellaneous)

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