Affiliation:
1. Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Washington, D.C.
Abstract
Formal, Samuel
B. (Walter Reed Army Institute of Research, Washington, D.C.),
E. H. LaBrec, H. Schneider, and Stanley Falkow
. Restoration of virulence to a strain of
Shigella flexneri
by mating with
Escherichia coli
. J. Bacteriol.
89:
835–838. 1965.—Three spontaneous avirulent variants of
Shigella flexneri
5 were isolated and employed as genetic recipients in matings with
Escherichia coli
K-12. The various hybrid classes isolated from these matings were subsequently examined for their ability to induce keratoconjunctivitis and to kill pretreated guinea pigs. All hybrids derived from two of the variants remained avirulent. A majority of the
mal
+
hybrids of the third avirulent variant were observed to be restored to complete virulence.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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