Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance-Reference-Cited by-同舟云学术

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Paloque Lucie¹²³^ORCID,Coppée Romain⁴,Stokes Barbara H.⁵,Gnädig Nina F.⁵,Niaré Karamoko⁶,Augereau Jean-Michel¹²³,Fidock David A.⁵⁷,Clain Jérôme⁴⁸,Benoit-Vical Françoise¹²³^ORCID

Affiliation:

1. LCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France

2. MAAP, New Antimalarial Molecules and Pharmacological Approaches, Toulouse, France

3. Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France

4. Université de Paris, MERIT, IRD, Paris, France

5. Department of Microbiology and Immunology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA

6. Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

7. Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA

8. Centre National de Référence du Paludisme, Laboratoire de Parasitologie, Hôpital Bichat-Claude Bernard, HUPNVS, APHP, Paris, France

Abstract

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum k13 ( pfk13 ) gene. Here, we carried out in vitro selection over a 1-year period on a West African P. falciparum strain isolated from Kolle (Mali) under a dose-escalating artemisinin regimen.

Funder

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01320-21

Reference72 articles.

1. Artemisinin Resistance inPlasmodium falciparumMalaria