Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra-Reference-Cited by-同舟云学术

Cloning and sequence analysis of a class A beta-lactamase from Mycobacterium tuberculosis H37Ra

Published:1997-05 Issue:5 Volume:41 Page:1182-1185
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hackbarth C J¹,Unsal I¹,Chambers H F¹

Affiliation:

1. Department of Medicine, University of California, San Francisco 94143, USA. corinne@itsa.ucsf.edu

Abstract

A cosmid library from Mycobacterium tuberculosis H37Ra was introduced into Mycobacterium smegmatis, and eight recombinant clones with increased resistance to cefoxitin were identified. Isoelectric focusing detected an M. tuberculosis-derived beta-lactamase in one of these recombinant clones. A sequence analysis identified it as a class A beta-lactamase whose expression correlated with the increased resistance phenotype.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.5.1182

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