MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

Author:

Zhang Keshan1ORCID,Yang Bo1,Shen Chaochao1,Zhang Ting1,Hao Yu1,Zhang Dajun1,Liu Huanan1,Shi Xijuan1,Li Guoli1,Yang Jinke1,Li Dan1ORCID,Zhu Zixiang1ORCID,Tian Hong1,Yang Fan1,Ru Yi1,Cao Wei Jun1,Guo Jianhong1,He Jijun1,Zheng Haixue1,Liu Xiangtao1

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

Abstract

African swine fever—an acute, febrile, hemorrhagic, highly contacting, and highly lethal disease caused by African swine fever virus (ASFV)—jeopardizes the global pig industry. Understanding the mechanism ASFV employs to evade host defense during infection is essential for developing targeted drugs and vaccines against ASFV.

Funder

Fundamental Research Funds of Chinses Academy of Agricultural Sciences

National Natural Science Foundation of China

The National Key Research and Development Program of China

The Major Science and Technology Project of Gansu Province

The Research funding from Lanzhou Veterinary Research Institute

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference48 articles.

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