Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying cfr , bla CTX-M-65 , fosA3 , and aac(6′)-Ib-cr in Proteus mirabilis-Reference-Cited by-同舟云学术

Characterization of a Novel SXT/R391 Integrative and Conjugative Element Carrying cfr , bla CTX-M-65 , fosA3 , and aac(6′)-Ib-cr in Proteus mirabilis

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lei Chang-Wei¹²,Chen Yan-Peng¹²,Kang Zhuang-Zhuang¹²,Kong Ling-Han¹²,Wang Hong-Ning¹²

Affiliation:

1. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, People's Republic of China

2. Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People's Republic of China

Abstract

A novel 139,487-bp SXT/R391 integrative and conjugative element, ICE Pmi ChnBCP11, was characterized in Proteus mirabilis of swine origin in China. ICE Pmi ChnBCP11 harbors 20 different antimicrobial resistance genes, including the clinically important rRNA methyltransferase gene cfr , the extended-spectrum β-lactamase gene bla CTX-M-65 , fosfomycin resistance gene fosA3 , and fluoroquinolone resistance gene aac(6′)-Ib-cr .

Funder

National Key Research and Development Program of China

Scientific Research Foundation of Sichuan University

International Collaborative Program of Sichuan Province

Miaozi Project in Science and Technology Innovation Program of Sichuan Province

China Postdoctoral Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00849-18