Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection-Reference-Cited by-同舟云学术

Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection

Published:2007-01 Issue:1 Volume:81 Page:434-438
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Day Cheryl L.¹²³,Kiepiela Photini²,Leslie Alasdair J.¹,van der Stok Mary²,Nair Kriebashne²,Ismail Nasreen²,Honeyborne Isobella¹,Crawford Hayley¹,Coovadia Hoosen M.²,Goulder Philip J. R.¹²³,Walker Bruce D.²³⁴,Klenerman Paul¹

Affiliation:

1. Nuffield Department of Medicine, The Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom

2. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa

3. Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115

4. Howard Hughes Medical Institute, Chevy Chase, Maryland 20185

Abstract

ABSTRACT The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major histocompatibility complex class I tetramers to examine responses to frequently targeted CD8 T-cell epitopes in a large cohort of antiretroviral-therapy-naïve HIV type 1 clade C virus-infected persons in KwaZulu Natal, South Africa. In terms of effector functions of proliferation, cytokine production, and degranulation, only proliferation showed a significant correlation with viral load. This robust inverse relationship provides an important functional correlate of viral control relevant to both vaccine design and evaluation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01754-06

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