HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage-Reference-Cited by-同舟云学术

HLA and HIV-1: Heterozygote Advantage and B*35 - Cw*04 Disadvantage

Published:1999-03-12 Issue:5408 Volume:283 Page:1748-1752
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Carrington Mary¹,Nelson George W.¹,Martin Maureen P.¹,Kissner Teri¹,Vlahov David²,Goedert James J.³,Kaslow Richard⁴,Buchbinder Susan⁵,Hoots Keith⁶,O'Brien Stephen J.⁷

Affiliation:

1. Intramural Research Support Program, Science Applications International Corporation Frederick, National Cancer Institute (NCI), Frederick, MD 21702–1201, USA.

2. The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA, for AIDS Linked to Intravenous Experience Cohort.

3. Viral Epidemiology Branch, NCI–Executive Plaza North, Bethesda, MD 20892, USA, for Multicenter Hemophilia Cohort Study.

4. University of Alabama, Birmingham, AL 35294, USA, for Multicenter AIDS Cohort Study.

5. San Francisco City Clinic Cohort, San Francisco, CA 94102, USA, for San Francisco City Cohort.

6. Gulf States Hemophilia Center, University of Texas Health Science Center, Houston, TX 77030, USA, for the Hemophilia Growth and Development Study.

7. Laboratory of Genomic Diversity, NCI, Frederick, MD 21702, USA.

Abstract

A selective advantage against infectious disease associated with increased heterozygosity at the human major histocompatibility complex [human leukocyte antigen ( HLA ) class I and class II] is believed to play a major role in maintaining the extraordinary allelic diversity of these genes. Maximum HLA heterozygosity of class I loci ( A , B , and C ) delayed acquired immunodeficiency syndrome (AIDS) onset among patients infected with human immunodeficiency virus–type 1 (HIV-1), whereas individuals who were homozygous for one or more loci progressed rapidly to AIDS and death. The HLA class I alleles B*35 and Cw*04 were consistently associated with rapid development of AIDS-defining conditions in Caucasians. The extended survival of 28 to 40 percent of HIV-1–infected Caucasian patients who avoided AIDS for ten or more years can be attributed to their being fully heterozygous at HLA class I loci, to their lacking the AIDS-associated alleles B*35 and Cw*04 , or to both.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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