HIV-1 Evolutionary Dynamics under Nonsuppressive Antiretroviral Therapy-Reference-Cited by-同舟云学术

HIV-1 Evolutionary Dynamics under Nonsuppressive Antiretroviral Therapy

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Kemp Steven A.¹^ORCID,Charles Oscar J.²^ORCID,Derache Anne³,Smidt Werner³^ORCID,Martin Darren P.⁴,Iwuji Collins³⁵,Adamson John³,Govender Katya³,de Oliveira Tulio³⁶,Dabis Francois⁷⁸,Pillay Deenan²,Goldstein Richard A.²^ORCID,Gupta Ravindra K.¹³^ORCID

Affiliation:

1. Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, United Kingdom

2. Division of Infection & Immunity, University College London, London, United Kingdom

3. Africa Health Research Institute, Durban, South Africa

4. Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa

5. Research Department of Infection and Population Health, University College London, United Kingdom

6. KRISP - KwaZulu-Natal Research and Innovation Sequencing Platform, UKZN, Durban, South Africa

7. INSERM U1219-Centre Inserm Bordeaux Population Health, Université de Bordeaux, France

8. Université de Bordeaux, ISPED, Centre INSERM U1219-Bordeaux Population Health, France

Abstract

HIV-1 infections are most commonly initiated with a single founder virus and are characterized by extensive inter- and intraparticipant genetic diversity. However, existing literature on HIV-1 intrahost population dynamics is largely limited to untreated infections, predominantly in subtype B-infected individuals.

Funder

Bill and Melinda Gates Foundation

Wellcome Trust

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00269-22

Reference73 articles.

1. Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants