Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function-Reference-Cited by-同舟云学术

Analysis of the Potential for N 4 -Hydroxycytidine To Inhibit Mitochondrial Replication and Function

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sticher Zachary M.¹,Lu Gaofei¹,Mitchell Deborah G.¹,Marlow Joshua¹,Moellering Levi¹,Bluemling Gregory R.¹²,Guthrie David B.¹,Natchus Michael G.¹,Painter George R.¹²³,Kolykhalov Alexander A.¹²

Affiliation:

1. Emory Institute for Drug Development, Emory University, Atlanta, Georgia, USA

2. Drug Innovation Ventures at Emory, Atlanta, Georgia, USA

3. Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

N 4 -Hydroxycytidine (NHC) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. It exhibits measurable levels of cytotoxicity, with 50% cytotoxic concentration values ranging from 7.5 μM in CEM cells and up to >100 μM in other cell lines.

Funder

DOD | Defense Threat Reduction Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01719-19

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1. Approved Antiviral Drugs over the Past 50 Years

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