Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat-Reference-Cited by-同舟云学术

Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat

Published:1995-08 Issue:15 Volume:177 Page:4528-4531
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bianchi V¹,Haggård-Ljungquist E¹,Pontis E¹,Reichard P¹

Affiliation:

1. Department of Genetics, Stockholm University, Sweden.

Abstract

Ferredoxin (flavodoxin) NADP+ oxidoreductase participates in methionine biosynthesis and in the function of two anaerobic enzymes, pyruvate formate-lyase and ribonucleotide reductase. We prepared insertion mutants of Escherichia coli lacking a functional enzyme. They do not require methionine and they grow well anaerobically, but they show increased sensitivity to paraquat.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.177.15.4528-4531.1995

Reference22 articles.

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3. Flavodoxin is required for the activation of the anaerobic ribonucleotide reductase;Bianchi V.;Biochem. Biophys. Res. Commun.,1993

4. Escherichia coli ferredoxin NADP~ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein;Bianchi V.;J. Bacteriol.,1993

5. Routes of flavodoxin and ferredoxin reduction in Escherichia coli;Blaschkowski H. P.;Eur. J. Biochem.,1982

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