Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis-Reference-Cited by-同舟云学术

Transcriptome-Wide Effects of NusA on RNA Polymerase Pausing in Bacillus subtilis

Published:2022-05-17 Issue:5 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Jayasinghe Oshadhi T.¹,Mandell Zachary F.¹,Yakhnin Alexander V.²,Kashlev Mikhail²,Babitzke Paul¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA

2. NCI RNA Biology Laboratory, Center for Cancer Research, NCI, Frederick, Maryland, USA

Abstract

NusA is an essential transcription elongation factor that was assumed to play a major role in RNAP pausing. NusA stimulates pausing in vitro ; however, the essential nature of NusA had prevented an assessment of its role in pausing in vivo .

Funder

Intramural Research Program

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00534-21

Reference33 articles.

1. Mechanisms of Transcriptional Pausing in Bacteria

2. The regulatory roles and mechanism of transcriptional pausing