A pause sequence enriched at translation start sites drives transcription dynamics in vivo-Reference-Cited by-同舟云学术

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

Published:2014-05-30 Issue:6187 Volume:344 Page:1042-1047
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Larson Matthew H.¹,Mooney Rachel A.²,Peters Jason M.³,Windgassen Tricia²,Nayak Dhananjaya²,Gross Carol A.³,Block Steven M.⁴⁵,Greenleaf William J.⁶,Landick Robert²⁷,Weissman Jonathan S.¹

Affiliation:

1. Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, California Institute for Quantitative Biosciences, Center for RNA Systems Biology, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA.

3. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Department of Biological Sciences, Stanford University, Stanford, CA 94025, USA.

5. Department of Applied Physics; Stanford University, Stanford, CA 94025, USA.

6. Department of Genetics, Stanford University, Stanford, CA 94025, USA.

7. Department of Bacteriology, University of Wisconsin, Madison, WI 53706, USA.

Abstract

Transcription takes a pause to consider A short sequence in DNA causes RNA polymerase (RNAP) to pause at thousands of previously undocumented locations in the genome. Larson et al. mapped these pause sites at single-nucleotide resolution in vivo in actively growing bacteria. Transcriptional pausing can be critical for the regulation of gene expression, by allowing RNA folding events and in the recruitment of other transcription factors. Science , this issue p. 1042

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference57 articles.

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4. Detection of transcription-pausing in vivo in the trp operon leader region.

5. Cooperation Between Translating Ribosomes and RNA Polymerase in Transcription Elongation

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