Population Pharmacokinetic Modeling and Probability of Target Attainment of Ceftaroline in Brain and Soft Tissues-Reference-Cited by-同舟云学术

Population Pharmacokinetic Modeling and Probability of Target Attainment of Ceftaroline in Brain and Soft Tissues

Published:2022-09-20 Issue:9 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Helfer Victória Etges¹,Zavascki Alexandre Prehn²³^ORCID,Zeitlinger Markus⁴^ORCID,de Araújo Bibiana Verlindo¹^ORCID,Dalla Costa Teresa¹^ORCID

Affiliation:

1. Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

2. Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

3. Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

4. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

Abstract

Ceftaroline, approved to treat skin infections and pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA), has been considered for the treatment of central nervous system (CNS) infections. A population pharmacokinetic (popPK) model was developed to describe ceftaroline soft tissue and cerebrospinal fluid (CSF) distributions and investigate the probability of target attainment (PTA) of the percentage of the dosing interval that the unbound drug concentration exceeded the MIC (% fT >MIC ) to treat MRSA infections.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Pfizer

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00741-22

Reference51 articles.

1. Pharmacokinetic and Pharmacodynamic Target Attainment in Adult and Pediatric Patients Following Administration of Ceftaroline Fosamil as a 5‐Minute Infusion