Author:
Sakoulas George,Nonejuie Poochit,Kullar Ravina,Pogliano Joseph,Rybak Michael J.,Nizet Victor
Abstract
ABSTRACTFive cases of bacterial meningitis treated with ceftaroline (4Streptococcus pneumoniaeand 1Staphylococcus aureus) are summarized here. The pharmacodynamics of human cathelicidin LL-37 and ceftaroline were evaluated againstS. pneumoniae. Patients who received ceftaroline 600 mg every 8 h (q8h) (1S. aureusand 3S. pneumoniae) were successfully treated; treatment failed in 1 patient withS. pneumoniaewho received 600 mg q12h. Ceftaroline increased the negative surface charge and sensitizedS. pneumoniaeto killing by LL-37, a peptide implicated in blood-brain barrier defense.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
22 articles.
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