1. Pharmacokinetics and PK/PD Modeling Laboratory, Pharmaceutical Sciences Graduate Program, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
2. Federal Laboratory of Animal and Plant Health and Inspection, Porto Alegre, Brazil
3. Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
4. Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil