DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae-Reference-Cited by-同舟云学术

DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae

Published:1995-02 Issue:2 Volume:39 Page:561-563
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Deguchi T¹,Yasuda M¹,Asano M¹,Tada K¹,Iwata H¹,Komeda H¹,Ezaki T¹,Saito I¹,Kawada Y¹

Affiliation:

1. Department of Urology, Gifu University, Japan.

Abstract

Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.39.2.561

Reference22 articles.

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