<i>Ehrlichia</i> SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes-Reference-Cited by-同舟云学术

Ehrlichia SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes

Published:2022-04-26 Issue:2 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Patterson LaNisha L.¹^ORCID,Velayutham Thangam Sudha¹,Byerly Caitlan D.¹,Bui Duc Cuong¹,Patel Jignesh¹,Veljkovic Veljko²,Paessler Slobodan¹^ORCID,McBride Jere W.¹³⁴⁵⁶^ORCID

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

2. Biomed Protection, LLC, Galveston, Texas, USA

3. Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

4. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA

5. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

6. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand mimicry cellular reprogramming strategy that involved a short linear motif (SLiM), which enabled E. chaffeensis to exploit host cell signaling to establish and maintain infection. E. chaffeensis TRP120 is a moonlighting effector that has been associated with cellular activation and other functions, including ubiquitin ligase activity.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

McLaughlin Endowment Predoctoral Fellowship

Biodefense Training Fellowship

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00076-22

Reference62 articles.

1. Amblyomma americanum ticks infected with in vitro cultured wild-type and mutants of Ehrlichia chaffeensis are competent to produce infection in naïve deer and dogs

2. Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection

3. Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling

4. Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival

5. Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte

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