Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling-Reference-Cited by-同舟云学术

Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Rogan Madison R.¹,Patterson LaNisha L.¹,Byerly Caitlan D.¹,Luo Tian¹^ORCID,Paessler Slobodan¹²^ORCID,Veljkovic Veljko²,Quade Bethany¹,McBride Jere W.¹³⁴⁵⁶^ORCID

Affiliation:

1. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

2. BiomedProtection, LLC, Galveston, Texas, USA

3. Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas, USA

4. Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA

5. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA

6. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Upon infecting mammalian hosts, Ehrlichia chaffeensis establishes a replicative niche in microbe-eating immune system cells where it expertly orchestrates infection and spread. One of the ways Ehrlichia survives within these phagocytes is by activating evolutionarily conserved signaling pathways including the Wnt pathway; however, the molecular details of pathway hijacking have not been defined.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00216-21

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