Deletion of a Cyclic AMP Receptor Protein Homologue Diminishes Germination and Affects Morphological Development of Streptomyces coelicolor-Reference-Cited by-同舟云学术

Deletion of a Cyclic AMP Receptor Protein Homologue Diminishes Germination and Affects Morphological Development of Streptomyces coelicolor

Published:2004-03-15 Issue:6 Volume:186 Page:1893-1897
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Derouaux A.¹,Halici S.²,Nothaft H.²,Neutelings T.¹,Moutzourelis G.¹,Dusart J.¹,Titgemeyer F.²,Rigali S.¹

Affiliation:

1. Centre d'Ingénierie des Protéines, Université de Liège, Institut de Chimie B6, B-4000 Liège, Belgium

2. Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91058 Erlangen, Germany

Abstract

ABSTRACT Open reading frame SCO3571 of Streptomyces coelicolor encodes a protein of the cyclic AMP (cAMP) receptor protein (CRP) superfamily of regulatory proteins. A mutant revealed a dramatic defect in germination, followed by growth delay and earlier sporulation. This phenotype correlates with those of an adenylate cyclase ( cya ) mutant that cannot synthesize cAMP. This finding suggests that S. coelicolor may use a Cya-cAMP-CRP system to trigger complex physiological processes such as morphogenesis.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.186.6.1893-1897.2004

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