Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16-Reference-Cited by-同舟云学术

Overexpression of Global Regulator SCrp Leads to the Discovery of New Angucyclines in Streptomyces sp. XS-16

Published:2023-04-14 Issue:4 Volume:21 Page:240
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Xu Xiao¹,Zhang Falei¹^ORCID,Zhou Luning¹,Chang Yimin¹,Che Qian¹,Zhu Tianjiao¹^ORCID,Li Dehai¹²^ORCID,Zhang Guojian¹²³^ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

2. Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China

3. Marine Biomedical Research Institute of Qingdao, Qingdao 266101, China

Abstract

Six angucyclines including three unreported compounds (1–3) were isolated from Streptomyces sp. XS-16 by overexpressing the native global regulator of SCrp (cyclic AMP receptor). The structures were characterized based on nuclear magnetic resonance (NMR) and spectrometry analysis and assisted by electronic circular dichroism (ECD) calculations. All compounds were tested for their antitumor and antimicrobial activities, and compound 1 showed different inhibitory activities against various tumor cell lines with IC50 values ranging from 0.32 to 5.33 μM.

Funder

National Natural Science Foundation of China

Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology

NSFC-Shandong Joint Fund

Publisher

MDPI AG

Subject

Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

https://www.mdpi.com/1660-3397/21/4/240/pdf

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