Characterization of Glucokinases from Pathogenic Free-Living Amoebae

Author:

Milanes Jillian E.1,Suryadi Jimmy1,Monaghan Neil P.1,Harding Elijah M.1,Morris Corbin S.1,Rozema Soren D.2,Khalifa Muhammad M.2,Golden Jennifer E.2ORCID,Phan Isabelle Q.3,Zigweid Rachael3,Abendroth Jan34,Rice Christopher A.5ORCID,McCord Hayden T.5ORCID,Wilson Stevin16,Fenwick Michael K.3ORCID,Morris James C.1ORCID

Affiliation:

1. Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, USA

2. School of Pharmacy, Pharmaceutical Sciences Division, University of Wisconsin—Madison, Madison, Wisconsin, USA

3. Seattle Structural Genomics Center for Infectious Disease, Center for Global Infection Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

4. UCB BioSciences, Bainbridge Island, Washington, USA

5. Pharmaceutical and Biomedical Sciences, Center for Drug Discovery, College of Pharmacy, University of Georgia, Athens, Georgia, USA

6. Genomics and Bioinformatics Facility, Clemson University, Clemson, South Carolina, USA

Abstract

Infection with pathogenic free-living amoebae, including Naegleria fowleri , Acanthamoeba spp., and Balamuthia mandrillaris , can lead to life-threatening illnesses, primarily because of catastrophic central nervous system involvement. Efficacious treatment options for these infections are lacking, and the mortality rate due to infection is high.

Funder

HHS | National Institutes of Health

Call Me Doctor Fellowship

Wisconsin Alumni Research Foundation

John and Jane Roudebush Distinguished Graduate Fellowship

Daniel H. Rich Distinguished Scholarship

National Science Foundation

Michigan Economic Development Corporation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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