Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase

Author:

Milanes Jillian E.1,Suryadi Jimmy1,Abendroth Jan2,Van Voorhis Wesley C.3,Barrett Kayleigh F.3,Dranow David M.2,Phan Isabelle Q.4,Patrick Stephen L.1,Rozema Soren D.5,Khalifa Muhammad M.5,Golden Jennifer E.5ORCID,Morris James C.1

Affiliation:

1. Eukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, USA

2. UCB Seattle/Seattle Structural Genomics Center for Infection Disease, Bainbridge Island, Washington, USA

3. Center for Emerging and Re-emerging Infectious Diseases Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA

4. Seattle Structural Genomics Center for Infectious Disease, Center for Global Infection Disease Research Seattle Children’s Research Institute, Seattle, Washington, USA

5. School of Pharmacy Pharmaceutical Sciences Division, University of Wisconsin–Madison, Madison, Wisconsin, USA

Abstract

Infection with the free-living amoeba Naegleria fowleri leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are limited, and the mortality rate is very high (∼98%).

Funder

HHS | National Institutes of Health

National Science Foundation

University of Wisconsin Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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