RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus-Reference-Cited by-同舟云学术

RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schildkraut Jodie A.¹^ORCID,Coolen Jordy P. M.¹^ORCID,Burbaud Sophie²,Sangen Jasper J. N.²,Kwint Michael P.³,Floto R. Andres²,op den Camp Huub J. M.⁴^ORCID,te Brake Lindsey H. M.⁵,Wertheim Heiman F. L.¹,Neveling Kornelia³,Hoefsloot Wouter⁶,van Ingen Jakko¹^ORCID

Affiliation:

1. Radboudumc Center for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, the Netherlands

2. University of Cambridge Molecular Immunity Unit, Department of Medicine, Cambridge, United Kingdom

3. Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands

4. Department of Microbiology, IWWR, Radboud University, Nijmegen, the Netherlands

5. Radboudumc Center for Infectious Diseases, Department of Pharmacy, Radboud University Medical Center, Nijmegen, the Netherlands

6. Radboudumc Center for Infectious Diseases, Department of Pulmonary diseases, Radboud University Medical Center, Nijmegen, the Netherlands

Abstract

Mycobacterium abscessus is an opportunistic pathogen notorious for its resistance to most classes of antibiotics and low cure rates. M. abscessus carries an array of mostly unexplored defense mechanisms. A deeper understanding of antibiotic resistance and tolerance mechanisms is pivotal in development of targeted therapeutic regimens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01509-21

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