Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium-Reference-Cited by-同舟云学术

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium

Published:2016-11-11 Issue:6313 Volume:354 Page:751-757
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bryant Josephine M.¹²,Grogono Dorothy M.²³,Rodriguez-Rincon Daniela²,Everall Isobel¹,Brown Karen P.²³,Moreno Pablo⁴,Verma Deepshikha⁵,Hill Emily⁵,Drijkoningen Judith²,Gilligan Peter⁶,Esther Charles R.⁶,Noone Peadar G.⁶,Giddings Olivia⁶,Bell Scott C.⁷⁸⁹,Thomson Rachel¹⁰,Wainwright Claire E.⁸¹¹,Coulter Chris¹²,Pandey Sushil¹²,Wood Michelle E.⁷⁸⁹,Stockwell Rebecca E.⁷⁸,Ramsay Kay A.⁷⁸,Sherrard Laura J.⁷,Kidd Timothy J.¹³¹⁴,Jabbour Nassib¹⁵¹⁶,Johnson Graham R.¹⁶,Knibbs Luke D.¹⁷,Morawska Lidia¹⁶,Sly Peter D.¹⁸,Jones Andrew¹⁹,Bilton Diana¹⁹,Laurenson Ian²⁰,Ruddy Michael²¹,Bourke Stephen²²,Bowler Ian C. J. W.²³,Chapman Stephen J.²³,Clayton Andrew²⁴,Cullen Mairi²⁵,Dempsey Owen²⁶,Denton Miles²⁷,Desai Maya²⁸,Drew Richard J.²⁹,Edenborough Frank³⁰,Evans Jason²¹,Folb Jonathan³¹,Daniels Thomas³²,Humphrey Helen³²,Isalska Barbara²⁵,Jensen-Fangel Søren³³,Jönsson Bodil³⁴,Jones Andrew M.²⁵,Katzenstein Terese L.³⁵,Lillebaek Troels³⁶,MacGregor Gordon³⁷,Mayell Sarah²⁹,Millar Michael³⁸,Modha Deborah³⁹,Nash Edward F.⁴⁰,O’Brien Christopher²²,O’Brien Deirdre⁴¹,Ohri Chandra³⁹,Pao Caroline S.³⁸,Peckham Daniel²⁷,Perrin Felicity⁴²,Perry Audrey²²,Pressler Tania³⁵,Prtak Laura³⁰,Qvist Tavs³⁵,Robb Ali²²,Rodgers Helen⁴³,Schaffer Kirsten⁴¹,Shafi Nadia³,van Ingen Jakko⁴⁴,Walshaw Martin⁴⁵,Watson Danie³⁸,West Noreen⁴⁶,Whitehouse Joanna⁴⁰,Haworth Charles S.³,Harris Simon R.¹,Ordway Diane⁵,Parkhill Julian¹,Floto R. Andres²³

Affiliation:

1. Wellcome Trust Sanger Institute, Hinxton, UK.

2. Molecular Immunity Unit, Department of Medicine, University of Cambridge, Medical Research Council (MRC)–Laboratory of Molecular Biology, Cambridge, UK.

3. Cambridge Centre for Lung Infection, Papworth Hospital, Cambridge, UK.

4. European Molecular Biology Laboratory (EMBL) European Bioinformatics Institute, Hinxton, UK.

5. Mycobacteria Research Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins CO, USA.

6. University of North Carolina School of Medicine, NC, USA.

7. Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Australia.

8. School of Medicine, The University of Queensland, Australia.

9. The Prince Charles Hospital (TPCH), Brisbane, Australia.

10. Gallipoli Medical Research Centre, University of Queensland, Brisbane, Australia.

11. Lady Cilento Children’s Hospital, Brisbane, Australia.

12. Queensland Mycobacterial Reference Laboratory, Brisbane, Australia.

13. Centre for Experimental Medicine, Queen’s University Belfast, Belfast, UK.

14. School of Chemistry and Biomolecular Sciences, University of Queensland, Brisbane, Australia.

15. Queensland University of Technology, Brisbane, Australia.

16. International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, Australia.

17. School of Public Health, University of Queensland, Brisbane, Australia.

18. Child Health Research Centre, University of Queensland, Brisbane, Australia.

19. Royal Brompton and Harefield National Health Service (NHS) Foundation Trust, London, UK.

20. Scottish Mycobacteria Reference Laboratory, Edinburgh, UK.

21. Wales Centre for Mycobacteria, Cardiff, UK.

22. The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK.

23. Oxford University Hospitals NHS Foundation Trust,Oxford, UK.

24. Nottingham University Hospitals NHS Trust, Nottingham, UK.

25. University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

26. Aberdeen Royal Infirmary, NHS Grampian, Scotland, UK.

27. The Leeds Teaching Hospitals NHS Trust, Leeds, UK.

28. Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK.

29. Alder Hey Children’s NHS Foundation Trust, Liverpool, UK.

30. Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

31. The Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK.

32. University Hospital Southampton NHS Foundation Trust, Southampton, UK.

33. Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

34. Department of Infectious Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

35. Copenhagen Cystic Fibrosis Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

36. International reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.

37. Gartnavel Hospital, Glasgow, NHS Greater Glasgow and Clyde, Scotland, UK.

38. Barts Health NHS Trust, London, UK.

39. University Hospitals of Leicester NHS Trust, Leicester, UK.

40. Heart of England NHS Foundation Trust, Birmingham, UK.

41. St Vincent’s University Hospital, Dublin, Ireland.

42. King’s College Hospital NHS Foundation Trust, London, UK.

43. Western General Hospital, NHS Lothian, Scotland, UK.

44. Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.

45. Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.

46. Sheffield Children’s NHS Foundation Trust, Sheffield, UK.

Abstract

Global spread of aggressive mycobacteria Many mycobacteria, in addition to those causing leprosy and tuberculosis, are capable of infecting humans. Some can be particularly dangerous in patients suffering from immunosuppression or chronic disease, such as cystic fibrosis (CF). Bryant et al. observed clusters of near-identical isolates of drug-resistant Mycobacterium abscessus in patients reporting to CF clinics. The similarity of the isolates suggests transmission between patients, rather than environmental acquisition. Although this bacterium is renowned for its environmental resilience, the mechanism for its long-distance transmission among the global CF patient community remains a puzzle. Science , this issue p. 751

Funder

Wellcome Trust

Medical Research Council

UK Cystic Fibrosis Trust

Papworth Hospital

National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre

NIHR Specialist Respiratory Biomedical Research Unit

UK Clinical Research Collaboration Translational Infection Research Initiative

CF Foundation Therapeutics

Australian National Health and Medical Research Council

The Prince Charles Hospital Foundation

National Services Division, NHS Scotland