Stepwise pathogenic evolution of Mycobacterium abscessus-Reference-Cited by-同舟云学术

Stepwise pathogenic evolution of Mycobacterium abscessus

Published:2021-04-30 Issue:6541 Volume:372 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bryant Josephine M.¹²^ORCID,Brown Karen P.¹³^ORCID,Burbaud Sophie¹^ORCID,Everall Isobel¹⁴^ORCID,Belardinelli Juan M.⁵^ORCID,Rodriguez-Rincon Daniela¹,Grogono Dorothy M.¹³^ORCID,Peterson Chelsea M.⁵^ORCID,Verma Deepshikha⁵^ORCID,Evans Ieuan E.¹³^ORCID,Ruis Christopher¹²^ORCID,Weimann Aaron¹²^ORCID,Arora Divya¹^ORCID,Malhotra Sony⁶⁷^ORCID,Bannerman Bridget¹²^ORCID,Passemar Charlotte¹^ORCID,Templeton Kerra⁸^ORCID,MacGregor Gordon⁸^ORCID,Jiwa Kasim⁹,Fisher Andrew J.⁹^ORCID,Blundell Tom L.⁶^ORCID,Ordway Diane J.⁵^ORCID,Jackson Mary⁵^ORCID,Parkhill Julian⁴¹⁰^ORCID,Floto R. Andres¹²³^ORCID

Affiliation:

1. Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC Laboratory of Molecular Biology, Cambridge, UK.

2. University of Cambridge Centre for AI in Medicine, Cambridge, UK.

3. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, UK.

4. Wellcome Sanger Institute, Hinxton, UK.

5. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins CO, USA.

6. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.

7. Scientific Computing Department, Science and Technology Facilities Council, Harwell, UK.

8. Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, Scotland, UK.

9. Newcastle University Translational and Clinical Research Institute and Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

10. Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Abstract

Jump starting pathogen evolution Mycobacteria are mostly environmental saprotrophs, but during human history, some have become our pathogens. In the past 50 years or so, intractable and virulent infections of Mycobacterium abscessus have emerged in people with cystic fibrosis. Bryant et al. investigated how these mycobacteria have evolved into human pathogens so quickly (see the Perspective by Brugha and Spencer). Chronic infections in the lung offer plenty of evolutionary scope for the emergence of virulent clones after horizontal gene transfer and hypermutation. Pathogens are acquired by environmental contamination, which leaves open a window for clinical control because the most virulent clones survive poorly outside the body. Therefore, immediate treatment and enhanced infection-control measures for M. abscessus cases could reduce opportunities for the evolution of direct person-to-person transmission. Science , this issue p. eabb8699 ; see also p. 465

Funder

Wellcome

Cystic Fibrosis Trust

Fondation Botnar

nihr biomedical research centre Cambridge

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference91 articles.

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2. US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis