Interleukin-6-Deficient Mice Are Highly Susceptible to Giardia lamblia Infection but Exhibit Normal Intestinal Immunoglobulin A Responses against the Parasite-Reference-Cited by-同舟云学术

Interleukin-6-Deficient Mice Are Highly Susceptible to Giardia lamblia Infection but Exhibit Normal Intestinal Immunoglobulin A Responses against the Parasite

Published:2003-03 Issue:3 Volume:71 Page:1569-1573
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bienz Marianne¹,Dai Wen Juan²,Welle Monika³,Gottstein Bruno¹,Müller Norbert¹

Affiliation:

1. Institute of Parasitology

2. Clinic for Rheumatology and Clinical Immunology/Allergology

3. Institute of Veterinary Pathology, University of Berne, Berne, Switzerland

Abstract

ABSTRACT In the present study, interleukin-6 (IL-6)-deficient mice were infected with Giardia lamblia clone GS/M-83-H7. Murine IL-6 deficiency did not affect the synthesis of parasite-specific intestinal immunoglobulin A. However, in contrast to wild-type mice, IL-6-deficient animals were not able to control the acute phase of parasite infection. Reverse transcription-PCR-based quantitation of cytokine mRNA levels in peripheral lymph node cells exhibited a short-term up-regulation of IL-4 expression in IL-6-deficient mice that seemed to be associated with failure in controlling the parasite population. This observation suggests a further elucidation of IL-4-dependent, Th2-type regulatory processes regarding their potential to influence the course of G. lamblia infection in the experimental murine host.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.71.3.1569-1573.2003

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