An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector-Reference-Cited by-同舟云学术

An Ixodes scapularis Protein Disulfide Isomerase Contributes to Borrelia burgdorferi Colonization of the Vector

Published:2020-11-16 Issue:12 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cao Yongguo¹²^ORCID,Rosen Connor³,Arora Gunjan²,Gupta Akash²,Booth Carmen J.⁴,Murfin Kristen E.²,Cerny Jiri²,Marin Lopez Alejandro²,Chuang Yu-Min²,Tang Xiaotian²,Pal Utpal⁵,Ring Aaron³,Narasimhan Sukanya²,Fikrig Erol²⁶

Affiliation:

1. Department of Clinical Veterinary Medicine, and Key Laboratory for Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China

2. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

3. Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA

4. Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

5. Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA

6. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

Abstract

Borrelia burgdorferi causes Lyme disease, the most common tick-transmitted illness in North America. When Ixodes scapularis feed on an infected vertebrate host, spirochetes enter the tick gut along with the bloodmeal and colonize the vector. Here, we show that a secreted tick protein, I . s capularis p rotein d isulfide i somerase A3 (IsPDIA3), enhances B. burgdorferi colonization of the tick gut.

Funder

Steven & Alexandra Cohen Foundation

Howard Hughes Medical Institute

HHS | NIH | OSC | Common Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00426-20

Reference41 articles.

1. Hair JA, Bowman J, Sauer J. 1986. Morphology, physiology and behavioural biology of ticks. Ellis Horwood, Chichester, UK.