Identification of the Shigella flexneri Wzy Domain Modulating Wzz <sub>pHS-2</sub> Interaction and Detection of the Wzy/Wzz/Oag Complex-Reference-Cited by-同舟云学术

Identification of the Shigella flexneri Wzy Domain Modulating Wzz _pHS-2 Interaction and Detection of the Wzy/Wzz/Oag Complex

Published:2022-09-20 Issue:9 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Ascari Alice¹^ORCID,Tran Elizabeth Ngoc Hoa¹,Eijkelkamp Bart A.²^ORCID,Morona Renato¹^ORCID

Affiliation:

1. School of Biological Sciences, Department of Molecular and Biomedical Science, Research Centre for Infectious Diseases, University of Adelaide, Adelaide, South Australia, Australia

2. Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia

Abstract

Shigella flexneri is a pathogen causing significant morbidity and mortality, predominantly devastating the pediatric age group in developing countries. A major virulence factor contributing to S. flexneri pathogenesis is its surface lipopolysaccharide, which is comprised of three domains: lipid A, core oligosaccharide, and O antigen (Oag).

Funder

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00224-22

Reference49 articles.

1. Membrane Topology Mapping of the O-Antigen Flippase (Wzx), Polymerase (Wzy), and Ligase (WaaL) from Pseudomonas aeruginosa PAO1 Reveals Novel Domain Architectures

2. Diversity and evolution of surface polysaccharide synthesis loci in Enterobacteriales

3. Synthesis of bacterial polysaccharides via the Wzx/Wzy-dependent pathway