Mutations in the gyrA , parC , and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis-Reference-Cited by-同舟云学术

Mutations in the gyrA , parC , and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis

Published:1999-04 Issue:4 Volume:43 Page:954-956
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bebear Cécile M.¹²,Renaudin Joel²,Charron Alain¹,Renaudin Hélène¹,de Barbeyrac Bertille¹,Schaeverbeke Thierry¹,Bebear Christiane¹

Affiliation:

1. Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux Cedex,1 and

2. Laboratoire de Biologie Cellulaire et Moléculaire, Institut National de la Recherche Agronomique, 33883 Villenave d’Ornon Cedex,2 France

Abstract

ABSTRACT Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance-determining regions of both DNA gyrase (GyrA) and topoisomerase IV (ParC or ParE). Furthermore, the novobiocin MIC for three isolates showed a significant increase. This is the first characterization of fluoroquinolone-resistant clinical mycoplasma isolates from humans.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.4.954

Reference21 articles.

1. Characterization of Mycoplasma hominis mutations involved in resistance to fluoroquinolones

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3. Alterations in Topoisomerase IV and DNA Gyrase in Quinolone-Resistant Mutants of Mycoplasma hominis Obtained In Vitro

4. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV

5. gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.;Contreras A.;Mol. Microbiol.,1992

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