Metagenomic Screening for Bleomycin Resistance Genes-Reference-Cited by-同舟云学术

Metagenomic Screening for Bleomycin Resistance Genes

Published:2008-11 Issue:21 Volume:74 Page:6803-6805
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Mori Toshio¹,Mizuta Shiori¹,Suenaga Hikaru¹,Miyazaki Kentaro¹²

Affiliation:

1. Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

2. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan

Abstract

ABSTRACT A metagenomic library of activated sludge was screened for bleomycin resistance genes. Two genes were identified that differed greatly from each other, from the genes of bleomycin-producing actinomycetes, and from those of clinical isolates. Therefore, the nonclinical environment is a rich reservoir of new resistance elements, and metagenomics can be used to sample the resistome rapidly.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00873-08

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5. Metagenomics: Application of Genomics to Uncultured Microorganisms

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