Sampling the Antibiotic Resistome-Reference-Cited by-同舟云学术

Sampling the Antibiotic Resistome

Published:2006-01-20 Issue:5759 Volume:311 Page:374-377
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

D'Costa Vanessa M.¹²,McGrann Katherine M.¹²,Hughes Donald W.¹²,Wright Gerard D.¹²

Affiliation:

1. Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5.

2. Department of Chemistry, McMaster University, Ontario, Canada, L8N 3Z5.

Abstract

Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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1. Practical Streptomyces Genetics 2000

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4. Glycopeptide Antibiotic Resistance Genes in Glycopeptide-Producing Organisms

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