Subtype B Human Immunodeficiency Virus (HIV) Type 1 Mutant That Escapes Detection in a Fourth-Generation Immunoassay for HIV Infection-Reference-Cited by-同舟云学术

Subtype B Human Immunodeficiency Virus (HIV) Type 1 Mutant That Escapes Detection in a Fourth-Generation Immunoassay for HIV Infection

Published:2004-06 Issue:6 Volume:42 Page:2847-2849
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gaudy Catherine¹,Moreau Alain¹,Brunet Sylvie¹,Descamps Jean-Michel²,Deleplanque Pascale²,Brand Denys¹,Barin Francis¹

Affiliation:

1. Laboratoire de Virologie, Equipe Associée 3250, Centre National de Référence du VIH, Centre Hospitalier Universitaire Bretonneau, Tours 37044

2. Centre Hospitalier, Niort, France

Abstract

ABSTRACT We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.42.6.2847-2849.2004

Reference8 articles.

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