Displacements of Prohead Protease Genes in the Late Operons of Double-Stranded-DNA Bacteriophages

Author:

Liu Jing1,Mushegian Arcady1

Affiliation:

1. Stowers Institute for Medical Research, Kansas City, Missouri 64110, and Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160

Abstract

ABSTRACT Most of the known prohead maturation proteases in double-stranded-DNA bacteriophages are shown, by computational methods, to fall into two evolutionarily independent clans of serine proteases, herpesvirus assemblin-like and ClpP-like. Phylogenetic analysis suggests that these two types of phage prohead protease genes displaced each other multiple times while preserving their exact location within the late operons of the phage genomes.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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