Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes-Reference-Cited by-同舟云学术

Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes

Published:2009-07-15 Issue:14 Volume:75 Page:4919-4922
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Tanaka Yukinori¹²,Komatsu Mamoru³,Okamoto Susumu¹,Tokuyama Shinji²,Kaji Akira⁴,Ikeda Haruo³,Ochi Kozo¹

Affiliation:

1. National Food Research Institute, Tsukuba, Ibaraki 305-8642, Japan

2. Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan

3. Kitasato Institute for Life Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan

4. School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Abstract

ABSTRACT Certain streptomycin resistance mutations (i.e., rpsL and rsmG ) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea , accompanied by increased transcription of a key developmental regulator gene, bldD , in the latter organism.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00681-09

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