Affiliation:
1. Department of Microbiology, Medical College of Ohio at Toledo, Toledo, Ohio 43614
Abstract
Cefatrizine (BL-S640), a semisynthetic, orally administered cephalosporin, was found to have an in vitro spectrum of activity comparable to those of four other cephalosporins tested. It is as effective as cephalexin, the other orally administered cephalosporin evaluated, against most species, and it appears to be more effective than cephalexin against many
Enterobacter, Haemophilus
, and
Proteus
strains isolated in our hospital. It is not inactivated by the plasmid-determined β-lactamases of 14 strains of ampicillin-resistant
Salmonella typhimurium
or the ampicillin resistance determinant of an
H. influenza
strain from the Center for Disease Control. No synergy was observed between cefatrizine and gentamicin, kanamycin, carbenicillin, or polymyxin when tested against selected strains.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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