Affiliation:
1. Department of Microbiological Research, Bristol Laboratories, Syracuse, New York 13201
Abstract
BL-S 640 was evaluated in vitro by comparison with cephalothin, cephaloridine, cefazolin, and cephalexin. The new compound was more active than the control cephalosporins against most major gram-negative and some gram-positive species. Moreover, its antibacterial spectrum included strains of
Enterobacter, Proteus morganii, P. rettgeri
, and
Providencia stuartii
, species generally resistant to the other cephalosporins. BL-S 640 was an effective bactericidal agent for strains of various species of
Enterobacteriaceae
. In human plasma, the compound was 58% protein bound.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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