Synthesis and antiproliferative activity of 1<i>H</i>-1,2,3-triazole-4<i>H</i>-chromene-<scp>d</scp>-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies-Reference-Cited by-同舟云学术

Synthesis and antiproliferative activity of 1H-1,2,3-triazole-4H-chromene-d-glucose hybrid compounds with dual inhibitory activity against EGFR/VEGFR-2 and molecular docking studies

Published:2022 Issue:48 Volume:46 Page:23179-23197
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Nguyen Dinh Thanh¹^ORCID,Do Son Hai¹²,Le Thi Huyen¹,Nguyen Thi Hanh¹,Nguyen Minh Huyen¹,Vu Thi Ngoc Bich¹,Pham Thi Thu Hien¹,Vu Ngoc Toan¹³,Hoàng Thi Kim Van¹⁴,Nguyen Thi Kim Giang¹²

Affiliation:

1. Faculty of Chemistry, VNU University of Science (Vietnam National University, Ha Noi), 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Vietnam

2. Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Vietnam

3. Institute of New Technology, Military Institute of Science and Technology, 17 Hoang Sam, Cau Giay, Ha Noi, Vietnam

4. Faculty of Chemical Technology, Viet Tri University of Industry, Tien Kien, Lam Thao, Phu Tho, Vietnam

Abstract

1H-1,2,3-Triazole-4H-chromene-d-glucose hybrids were synthesized and screened for their anticancer activity in vitro against MCF-7, HepG2, HeLa and WI-38 cells, and several had dual inhibitions against EGFR/VEGFR-2. IFD, MM-GBSA and MD simulations were also carried out.

Funder

National Foundation for Science and Technology Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ04373D

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