Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells-Reference-Cited by-同舟云学术

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Published:2021-08-17 Issue:9 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Li Ruidong¹,Liclican Albert¹,Xu Yili¹,Pitts Jared¹,Niu Congrong¹,Zhang Jingyu¹,Kim Cynthia¹,Zhao Xiaofeng¹,Soohoo Daniel¹,Babusis Darius¹,Yue Qin¹,Ma Bin¹,Murray Bernard P.¹,Subramanian Raju¹,Xie Xuping²^ORCID,Zou Jing²,Bilello John P.¹,Li Li¹,Schultz Brian E.¹,Sakowicz Roman¹,Smith Bill J.¹,Shi Pei-Yong²,Murakami Eisuke¹,Feng Joy Y.¹^ORCID

Affiliation:

1. Gilead Sciences, Inc., Foster City, California, USA

2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized in multiple steps to form the active nucleoside triphosphate (TP) (GS-443902), which, in turn, acts as a potent and selective inhibitor of multiple viral RNA polymerases.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00602-21

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