Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys-Reference-Cited by-同舟云学术

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

Published:2023-08-19 Issue:17 Volume:66 Page:11701-11717
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mackman Richard L.¹^ORCID,Kalla Rao V.¹,Babusis Darius²,Pitts Jared³,Barrett Kimberly T.⁴^ORCID,Chun Kwon¹,Du Pont Venice³,Rodriguez Lauren⁵,Moshiri Jasmine⁵,Xu Yili⁶,Lee Michael⁷,Lee Gary⁷,Bleier Blake⁴,Nguyen Anh-Quan⁴,O’Keefe B. Michael⁸^ORCID,Ambrosi Andrea⁸^ORCID,Cook Meredith⁸,Yu Joy⁸,Dempah Kassibla Elodie⁹^ORCID,Bunyan Elaine⁹,Riola Nicholas C.³,Lu Xianghan³,Liu Renmeng²,Davie Ashley²,Hsiang Tien-Ying¹⁰,Dearing Justin¹¹,Vermillion Meghan¹¹,Gale Michael¹⁰,Niedziela-Majka Anita⁷,Feng Joy Y.⁶,Hedskog Charlotte⁵,Bilello John P.³,Subramanian Raju²^ORCID,Cihlar Tomas³

Affiliation:

1. Medicinal Chemistry, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

2. Drug Metabolism, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

3. Discovery Virology, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

4. Formulation and Process Development, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

5. Clinical Virology, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

6. Biochemistry, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

7. Biology, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

8. Process Chemistry, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

9. Process Development, Gilead Sciences Incorporated, 333 Lakeside Drive, Foster City, California 94404 United States

10. Center for Innate Immunity and Immune Disease, Department of Immunology, School of Medicine, University of Washington, Seattle, Washington 98109 United States

11. Lovelace Biomedical Research Institute, 2425 Ridgecrest Drive Southeast, Albuquerque, New Mexico 87108 United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00750

Reference43 articles.

1. https://covid19.who.int/ (Accessed Feb 26, 2023).

2. Coronavirus biology and replication: implications for SARS-CoV-2