RNAIII-Inhibiting Peptide Affects Biofilm Formation in a Rat Model of Staphylococcal Ureteral Stent Infection

Author:

Cirioni Oscar1,Ghiselli Roberto2,Minardi Daniele3,Orlando Fiorenza4,Mocchegiani Federico2,Silvestri Carmela1,Muzzonigro Giovanni1,Saba Vittorio2,Scalise Giorgio1,Balaban Naomi5,Giacometti Andrea1

Affiliation:

1. Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy

2. Department of General Surgery, I.N.R.C.A.-I.R.R.C.S., Polytechnic University of the Marche Region, Ancona, Italy

3. Institute of Maternal and Children's Sciences—Urology, Polytechnic University of the Marche Region, A.O. Ospedali Riuniti, Ancona, Italy

4. Experimental Animal Models for Aging Units, Research Department, I.N.R.C.A.-I.R.R.C.S., Ancona, Italy

5. Tufts University, Cummings School of Veterinary Medicine, Department of Biomedical Sciences, North Grafton, Massachusetts 01536

Abstract

ABSTRACT Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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