Autoinducer of Virulence As a Target for Vaccine and Therapy Against Staphylococcus aureus-Reference-Cited by-同舟云学术

Autoinducer of Virulence As a Target for Vaccine and Therapy Against Staphylococcus aureus

Published:1998-04-17 Issue:5362 Volume:280 Page:438-440
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Balaban Naomi¹²³⁴,Goldkorn Tzipora¹²³⁴,Nhan Rachael T.¹²³⁴,Dang Luong B.¹²³⁴,Scott Steven¹²³⁴,Ridgley Rose M.¹²³⁴,Rasooly Avraham¹²³⁴,Wright Susan C.¹²³⁴,Larrick James W.¹²³⁴,Rasooly Reuven¹²³⁴,Carlson James R.¹²³⁴

Affiliation:

1. N. Balaban, R. T. Nhan, S. Scott, R. M. Ridgley, R. Rasooly, J. R. Carlson, Department of Medical Pathology, University of California, Davis, CA 95616, USA.

2. T. Goldkorn and L. B. Dang, Department of Internal Medicine, University of California, Davis Medical Center, Davis, CA 95616, USA.

3. A. Rasooly, Department of Microbiology, University of Maryland, College Park, MD 20742, USA.

4. S. C. Wright and J. W. Larrick, Palo Alto Research Institute of Molecular Medicine, Mountain View, CA 94043, USA.

Abstract

Staphylococcus aureus causes pathologies ranging from minor skin infections to life-threatening diseases. Pathogenic effects are largely due to production of bacterial toxin, which is regulated by an RNA molecule, RNAIII. The S. aureus protein called RAP (RNAIII activating protein) activates RNAIII, and a peptide called RIP (RNAIII inhibiting peptide), produced by a nonpathogenic bacteria, inhibits RNAIII. Mice vaccinated with RAP or treated with purified or synthetic RIP were protected from S. aureus pathology. Thus, these two molecules may provide useful approaches for the prevention and treatment of diseases caused by S. aureus .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. S. C. Silverstein and T. H. Steinberg in Microbiology B. D. Davis R. Dulbecco H. N. Eisen H. S. Ginsberg Eds. (Lippincott Philadelphia 1990) pp. 485–506.

2. Panlilio A. L., et al., Infect. Control Hosp. Epidemiol.13, 582 (1992).

3. Novick R. P., et al., EMBO J.12, 3967 (1993).

4. Balaban N., Novick R. P., FEMS Microbiol. Lett.133, 155 (1995).

5. Moerfeldt E., Taylor D., Von Gabain A., Arvidson S., EMBO J.14, 4569 (1995).

Cited by 204 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deciphering agr quorum sensing in Staphylococcus aureus: insights and therapeutic prospects;Molecular Biology Reports;2024-01-22

2. Oral Vaccination with Engineered Probiotic Limosilactobacillus reuteri Has Protective Effects against Localized and Systemic Staphylococcus aureus Infection;Microbiology Spectrum;2023-04-13

3. The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus;Virulence;2023-02-10

4. New insight into old and new antimicrobial molecules targeting quorum sensing for MRSA wound infection;Future Microbiology;2022-02

5. New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing;Antibiotics;2021-11-10