Treatment of Staphylococcus aureus Biofilm Infection by the Quorum-Sensing Inhibitor RIP-Reference-Cited by-同舟云学术

Treatment of Staphylococcus aureus Biofilm Infection by the Quorum-Sensing Inhibitor RIP

Published:2007-06 Issue:6 Volume:51 Page:2226-2229
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Balaban Naomi¹,Cirioni Oscar²,Giacometti Andrea²,Ghiselli Roberto³,Braunstein Joel B.⁴,Silvestri Carmela²,Mocchegiani Federico³,Saba Vittorio³,Scalise Giorgio²

Affiliation:

1. Department of Biomedical Sciences, Division of Infectious Diseases, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536

2. Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy

3. Department of General Surgery, INRCA, IRRCS, University of Ancona, Ancona, Italy

4. Centegen Inc. Baltimore, Maryland 21208

Abstract

ABSTRACT The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/ agr systems and both TRAP- and agr -negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01097-06

Reference41 articles.

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