Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis-Reference-Cited by-同舟云学术

Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alves Michel Muálem de Moraes¹²^ORCID,Arcanjo Daniel Dias Rufino¹^ORCID,Figueiredo Kayo Alves¹³,Oliveira Jéssica Sara de Sousa Macêdo⁴,Viana Felipe José Costa⁵,Coelho Elvilene de Sousa³,Lopes Glaucia Lais Nunes³,Gonçalves Juan Carlos Ramos¹⁶,Carvalho André Luís Menezes³,Rizzo Márcia dos Santos⁵^ORCID,Chaves Mariana Helena⁴,Mendonça Ivete Lopes de⁷,Carvalho Fernando Aécio de Amorim¹

Affiliation:

1. Antileishmanial Activity Laboratory, Medicinal Plants Research Center, Federal University of Piaui, Teresina, Piauí, Brazil

2. Department of Veterinary Morphophysiology, Federal University of Piauí, Teresina, Piauí, Brazil

3. Laboratory of Dermopharmacy, Faculty of Pharmacy, Federal University of Piauí, Teresina, Piauí, Brazil

4. Laboratory of Natural Products, Department of Chemistry, Federal University of Piauí, Teresina, Piauí, Brazil

5. Histotechnical Laboratory, Department of Morphology, Federal University of Piauí, Teresina, Piauí, Brazil

6. Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil

7. Department of Veterinary Clinics and Surgery, Federal University of Piauí, Teresina, Piauí, Brazil

Abstract

In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and with ellagic acid (EA) in topical formulations for the treatment of cutaneous leishmaniasis in BALB/c mice. Preliminary stability tests of the formulations and in vitro drug release studies with Amph B, GA, Amph B plus GA, EA, and Amph B plus EA were carried out, as well as assessment of the in vivo treatment of BALB/c mice infected with Leishmania major .

Funder

Fundação de Amparo à Pesquisa do Estado do Piauí

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00807-20

Reference54 articles.

1. Leishmaniasis Worldwide and Global Estimates of Its Incidence

2. 10-Year Trends in Epidemiology, Diagnosis, and Treatment of Cutaneous Leishmaniasis in Hamadan Province, West of Iran (2007–2016)

3. Leishmaniasis impact and treatment access