Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Genome-Wide Transposon Mutagenesis Screens Identify Group A Streptococcus Genes Affecting Susceptibility to β-Lactam Antibiotics

Published:2022-12-20 Issue:12 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Zhu Luchang¹²³,Eraso Jesus M.¹²³,Mangham Regan E.¹²,Ojeda Saavedra Matthew¹²,Olsen Randall J.¹²³,Beres Stephen B.¹²^ORCID,Musser James M.¹²³

Affiliation:

1. Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, Texas, USA

2. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA

3. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA

Abstract

Beta-lactam antibiotics are the primary drugs prescribed to treat infections caused by group A streptococcus (GAS), an important human pathogen. However, the molecular mechanisms of GAS interactions with beta-lactam antibiotics are not fully understood.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00287-22

Reference48 articles.

1. Group A Streptococcal Diseases and Their Global Burden

2. Status of research and development of vaccines for Streptococcus pyogenes

3. Beta-Lactam Antibiotics Induce a Lethal Malfunctioning of the Bacterial Cell Wall Synthesis Machinery