First Description of an RND-Type Multidrug Efflux Pump in Achromobacter xylosoxidans, AxyABM-Reference-Cited by-同舟云学术

First Description of an RND-Type Multidrug Efflux Pump in Achromobacter xylosoxidans, AxyABM

Published:2011-08-01 Issue:10 Volume:55 Page:4912-4914
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Bador Julien,Amoureux Lucie,Duez Jean-Marie,Drabowicz Anthony,Siebor Eliane,Llanes Catherine,Neuwirth Catherine

Abstract

ABSTRACTAchromobacter xylosoxidansis an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter componentaxyBgene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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