Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of <i>Achromobacter</i> Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide-Reference-Cited by-同舟云学术

Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

MacDonald Lewis¹,Keenan Sean¹,Di Lorenzo Flaviana²³,Adade Nana E.¹⁴,Kenna Dervla T. D.⁵,Millar Beverley C.¹⁶,Moore John E.¹⁶,Ramos Vivas José⁷⁸,Molinaro Antonio²⁹,Valvano Miguel A.¹^ORCID

Affiliation:

1. Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom

2. Department of Chemical Sciences, University of Naples Federico II, Naples, Italy

3. Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy

4. West African Center for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana

5. Antimicrobial Resistance and Healthcare Associated Infections Unit, UK Health Security Agency, London, United Kingdom

6. Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Belfast City Hospital, Belfast, United Kingdom

7. Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain

8. CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain

9. Department of Chemistry, School of Science, Osaka University, Osaka, Japan

Abstract

Achromobacter species can cause chronic and potentially severe infections in immunocompromised patients, especially in those with cystic fibrosis. Bacteria cannot be eradicated due to Achromobacter 's intrinsic multidrug resistance.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03729-22

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