Efficacy of Liposomal Amphotericin B in Treatment of Systemic Murine Fusariosis-Reference-Cited by-同舟云学术

Efficacy of Liposomal Amphotericin B in Treatment of Systemic Murine Fusariosis

Published:2002-07 Issue:7 Volume:46 Page:2273-2275
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ortoneda Montserrat¹,Capilla Javier¹,Pastor Francisco J.¹,Pujol Isabel²,Guarro Josep¹

Affiliation:

1. Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut and Institut d'Estudis Avançats

2. Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus, Universitat Rovira i Virgili, 43201 Reus, Spain

Abstract

ABSTRACT We have compared the activities of liposomal amphotericin B (LAMB) at 3, 5, 10, and 20 mg/kg/day and amphotericin B deoxycholate (AMB) at 1.5 and 2.5 mg/kg/day in a murine systemic infection by Fusarium verticillioides . Survival was improved by all treatments except AMB at 1.5 mg/kg/day. The tissue burden in liver was reduced by LAMB at all dosages and by AMB at 2.5 mg/kg/day. The two highest dosages of LAMB showed significant reductions in the spleen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.7.2273-2275.2002

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